AN INTERVIEW WITH JAMES AKAGI Interviewer: Jewell Willhite Oral History Project KU Retirees' Club University of Kansas JAMES AKAGI B.S., Bacteriology, University of Illinois, 1951 M.A., Bacteriology, University of Kansas, 1955 Ph.D., Bacteriology, University of Kansas, 1959 P-D, Western Reserve University School of Medicine, 1959-61 Service at the University of Kansas Instructor, 1958 Assistant Professor, 1961 Associate Professor, 1964 Professor, 1967 Emeritus, 1995 James Akagi Interviewer: Jewell Willhite Q: I am speaking with James Akagi, who retired in 1995 professor of microbiology at the University of Kansas . in Lawrence, Kansas, on September 25, 1995. as We are Where were you born and in what year? A: I was born in Seattle, Washington, on Dec. 23, 1927. Q: What were your parents' names? A: My father's name is Teiji Akagi and my mother's name is Yone. Q: What was their educational background? A: My father was a second son in Japan. everything and the nothing. second The first son gets and third and any Only the first son gets everything. the Samurai sword, the home and everything. sons of most of the people would emigrate. them who came to this somewhere around there. They settled in Seattle, get My father's The first son got everything, family was a Samurai family. of females country, So the second My father was one about 1919 or 1920, My mother came later as his bride. Washington. sisters and a younger brother. I have three older There are five of us. Q: What was your father's occupation? A: He ran a produce house, that is to say he would get all the produce from the farmers around Seattle and pack them up and ship them off to various cities . store. Q: Did you grow up in Seattle? 1 He also operated a grocery A: Yes, I grew up in Seattle until I starting high school. In 1942 we all was 14 years old, just And that's when World War II broke out. had to go into these camps, so-called concentration camps in the United States. Q: I've heard of that . A: To Minidoka, Idaho. Where did your family go? That's just by Twin Falls. There were 10 of these camps scattered throughout the United States in the interior away from the West Coast with approximately 10,000 in each camp. There were a total of 120,000 Japanese on the West Coast, and they were all evacuated into these camps. Q: That would be like a small town. A: It wasn't like a town. There were barracks, barbed wire fences and guard towers and guards and everything. It was a concentration camp, as Roosevelt and Truman admitted. were not just camps. concentration involved. camps These These were what they would consider with limited movement by the people So we were in this camp up until 1945, three years. Q: So you went to elementary school back in Seattle. A: Elementary school in Seattle through eighth grade and I had just started the ninth grade when we were evacuated. the ninth, tenth, and eleventh grades, So for I went to school in camp. Q: so you graduated from high school while you were in camp. A: I was in the last graduation class in 1945 when I graduated. Q: Did your father lose his business when your family went to the camp? 2 A: Yes, everyone that was evacuated had very short notice to evacuate. There were some who had only 24 hours. two weeks. some had To get rid of everything in that period of time was virtually impossible. And so a lot of people were coming around buying material very cheaply, and the people had to get rid of their property for whatever they could get. There were some very people who were fortunate to have some good Caucasian friends who said they would take care of their property for them, which they did, until the war ended. most of the people were left with nothing. But Because of that, President Reagan signed in 1988 this entitlement to pay every person $20,000, which didn't cover it all but it was some way of saying they apologize. ( Q: Did your family go back to Seattle when you were released? A: No, there was nothing for us to go back to because we had nothing there in 1945. Our family relocated to Chicago, Illinois, and made a new start. Q: Did you have relatives there? A: No, nothing. Q: Your father just chose Chicago? A: Well, not my father or my mother. over. By then the children took They (parents) were called Issei, the first generation in this country. We are the Nisei, the second generation . The second generation people are American citizens because we were born here . The first generation was not. law that was passed, Because of the they could not become naturalized or 3 anything. They were not citizens. The law was passed in 1924 or something saying no person from any part of Asia could become an American citizen or become naturalized. So my parents, like any other Nisei people's parents, could not own property. The property that they had, many Issei used to take it out in the name of their oldest child, in our case it was my oldest sister. Not only that, they couldn't speak English very well and our generation was slowly getting older . The average age (of the Nisei) at that time in 1942 was about 17, so we were not old enough to take charge of everything. Some people fought the evacuation and said they would not go. They were put in jail for the duration of the war. were so young, said. But because we we had to just go along with whatever they And then in camp it was the older children who decided what the family would do. go to Chicago. whatever their And so my sisters decided we would By then most of the parents just followed children told children told them to go. them to do, wherever their So we came to Chicago and I started college there in 1945. Q: What school did you go to? A: I went to a junior college in Chicago. junior college . Now it is a four-year college. North Park Junior College at that time. course. It was called I just took a general That first year you have no choice. requirements. Q: At that time it was a You take certain I played baseball for the college. Had you played baseball before in the camp? 4 A: We played a lot in camp. Q: I suppose, to have something to do. A: We played a lot of baseball, a lot of football, a lot of ping pong, a lot of pinochle. We had a lot of time in camp because there was nothing to do. We had a lot of spare time and we learned to do everything. Most of the young ones my age, from 14 to 17, played a lot of sports . So anyway my first year in Chicago I went to college and played baseball. After the end of that year I was 18 years old and was getting ready to be drafted by the Army, because the draft was still on. So I went into the Army in 1946. Q: Where did you go for your training then? A: I went through basic training at Fort McClellan, Alabama. Then from there the Army sort of got mixed up on my records. My outfit went to Korea but I was left behind through a mixup. A very kind colonel knew that I came from the West Coast . He had fought with a lot of Japanese-Americans in Europe and he said he would like to do something for me. He said, "Would you like to go to the West Coast?" I said, "Sure. to go back up to Seattle. 11 11 He said, with your company to Korea. the West Coast. " All right. I'd love You won't go I'll make orders for you to go to And so I stayed behind . But the Army got it all mixed up, like they always do, and I didn't go to the West Coast. I direction. went to Fort Dix, New Jersey, in the opposite They didn't know what I was there for. After three or four months of just doing nothing, they said they 5 would send me to school in the Army . And they sent me down to Fort Sam Houston in San Antonio, to laboratory school, where I came across microbiology, hematology, all the things you do in a medical lab. Q: Were they training you to be a medic? A: A medical lab technician, one who works in laboratories. So that's the school I went to, where I was first introduced to microbiology, that I found fascinating. The Army, just before I finished laboratory school, ordered me to go to Washington, D.C., to the Pentagon. I Why me, I don't know. But they said had to teach the people there how to do what they call venipuncture, take blood from people, because that's what we learned at the school in San Antonio. I was stationed at Fort Myer, Virginia, which is just outside of Washington. sent me to the Pentagon every day with a staff car . a ride every morning and I went down and I They So I got worked in the Pentagon drawing blood from people , dependents who were going overseas to join their husbands. blood tests . They all had to have their And they had no one qualified to do this. that's why they got me. I was the one drawing blood from the people going over to Europe. there how to do it. So And I taught the technicians Finally, they were in a position where they could do the blood taking without me. Then I was just stationed at Fort Myer and didn't have to go to the Pentagon any more after about three months . I was assigned to the Fort Myer medical laboratory, where I worked until my discharge i n 6 1948. In 1948, returned to after being discharged from the Army, Chicago and enrolled at the University I of Illinois . Q: Had you always expected that you would go to college? A: Oh, yes. From the time I was very young my parents said I was going to college. One of my sisters also did. sister is very talented. She is a violinist . My middle During the war while we were in camp she went out of camp and went to Oberlin, to the music conservatory there and got her degree in music. She went on to play with the Kansas City Symphony, the St. Louis Symphony and got accepted by the Chicago Symphony until they found out she was a girl. to be. It was all men, it used Because of her name--she used "Terry"--they thought she was a he, until she went up for her interview and they ( couldn't accept her on the symphony because at that time--I don't know how it is now--it was an all-male symphony. She eventually married another person from the st. Louis Symphony and they went to Hollywood where they were playing in the movies and the TV and the Los Angeles Symphony. professional musicians. Q: They were They are now retired. So you went back and went to the University of Illinois. Were you majoring in microbiology? A: That's right. there I I got my bachelor's degree there . While I was met another graduate student at that time in the department who came from Kansas. well-known microbiologist, He later on became a very biochemist. 7 He was telling me about possible places to go, because in those years the general policy of people graduating from any university was not to go on to graduate school at that same university. try to send you away. So I was looking for a place to go. said Kansas was a pretty good place. accepted at Kansas. time. They He And so I applied and got I was still on the G.I . Bill at that Because I was in the Army for two years, I had a total of 36 months. It is the total amount of time plus twelve months that they give you. So I had 36 months of schooling. So I had one year to begin with and I had three years left and that was 27 months and I had one more year so I used that to come to Kansas in graduate school . courses here on the G.I. Bill. And I came here and took I didn't have any financial aid at that time, so after one year I said that since I had no financial aid I would go back to Chicago and work. in a consulting laboratory for breweries I worked testing beer, analyzing beer because a lot of breweries have microbiological problems. And I worked there until Dave Paretsky at the department here at Kansas University got some money and he got word to me that he had a research assistantship for me if I would come back to college. So the next year I came back and pursued a master's degree and then eventually a Ph.D. Q: Was he your major professor? A: He was my professor. Q: Did you write a thesis for your master's? He was my mentor. 8 A: Yes, I wrote a thesis for my master's. Q: What were you studying for your master's? A: My major interest biochemistry . in graduate school in microbiology was I love chemistry, and so I applied chemistry to microbiology, which is essentially biochemistry. And so it was a biochemical problem for my master's degree, something about a protein I put together and a similar sort of thing for my Ph.D. my Ph.D. I just followed it up and did a chemical problem for I graduated in 1959 with a Ph.D. Q: Do you remember any other influential teachers from that time? A: Oh, yes. One person who was very influential was Dr. Ray Brewster, who was chairman of Chemistry. He was the one who really excited me in organic chemistry, and he was a very stimulating teacher. He was very, very good. Dr. McEwen at that time was another organic chemistry teacher. got me very much interested in chemistry, becoming a chemistry microbiology. major I applied They just and instead of that chemistry to Because of that, all my students went the same route that I did. They all had to learn their chemistry. So that was the basis of my so-called program in microbiology for graduate students. Q: What building was that in at that time? A: We were in old Snow Hall . work and We were doing all the microbiology teaching microbiology and everything. All the biological sciences were in Snow Hall, other than a couple departments, such as biochemistry in old Haworth . 9 We were in Snow Hall until 1969 when they built the so-called new Haworth Hall and we moved into that department in 1969. Q: Did you teach for the first time while you were a graduate student? A: Yes . My degree was in 1959 but I actually finished the work in 1958, just after the deadline . So Dr . Paretsky said he would keep me on as an instructor where I could teach that whole academic year until 1959, because that's when my degree was actually conferred . So I stayed on until 1959. During that year I was looking around for a postdoctoral position . I found one with Western Reserve University Medical School . So my postdoctoral year after 1959 was spent in Cleveland , Ohio, at Western Reserve, now known as Case Western Reserve. So ( I spent two microbiology. years I got there furthering introduced to a my chemistry whole new group and of microorganisms by a person, Leon Campbell, a very well-known individual . He later became the president of the American Society for Microbiology , which is a very great honor . But he was a young person who had lots of ideas and when I talked to him before I took a postdoctoral with him, he said coming over to Western Reserve would be very nice, that we could do some work together. I had almost committed myself to Johns Hopkins at that time. But at the last second I changed my mind and went to Western Reserve. Q: Were you married at this time? A: I got married one year into my post doc . 10 My first year in Cleveland I was not married. But my fiancee was here. was a graduate student in the department of microbiology. so I She And came back after the first year and we got married on August 3, 1960 . Q: What was her name? A: Barbara Jean West. And we went back to Cleveland to finish my postdoctoral at that time . which ended in 1961, I was looking for a postdoctoral training , years. After my postdoctoral training, like internships, After that one goes to a job. and I was considering an offer I this is Chicago. I told you I job because most are generally two I was looking around got from Northwestern but had lived in Chicago for a while, and I thought that this is not the place to raise a family. So having known Lawrence for a while, and not only that, my wife ' s family were right in Missouri, so she was very excited about coming back here . Dave Paretsky at that time was chairman and he offered me a position here. So that's how I ended up back in Kansas in 1961 . Q: What were you teaching at KU? A: I taught mainly courses in my field, which we called microbial physiology or microbial biochemistry. teach introductory microbiology. microbiology. So I But all of us had to taught introductory I taught microbial biochemistry . I introduced another course later on called applied microbiology because by then people were becoming interested in the applications of microbiology . So I thought I 11 could use some of my prior experience working at the consulting laboratory for breweries on how microbiologists could utilize their knowledge in analyzing foods as well as how to make wine, how to make beer , cheese and all this . part was mostly So it was a course in which the lecture biochemical but actually making these products, the laboratory like yogurt, part was cheese, wine, sauerkraut. Q: That must have been an interesting lab. A: The kids loved it. They enjoyed it very much. That was an undergraduate course . Q: Did you teach some undergraduate and some graduate courses? A: Yes. I taught undergraduate introductory courses, which I enjoyed very much, applied microbiology, and graduate courses until 1967 . ( I came here in 1961 as an assistant professor . In 1964 I was an associate professor. professor. In 1967 I In 1967 I became a full also received a government research award, a research career development award. That award was that the government would pay the recipient's total salary, 12 months' salary, and the university would agree to hire someone else to take the recipient's place in teaching, if they wanted to. Q: So that you could do just research . A: That's right. I got this award for 1967 for five years and I got a renewal for another five. For a total of ten years I was on this research career development award in which I did not have to teach at all, just do nothing but research because 12 I qualified and competed well enough to get it. But I wanted to continue teaching, so I did teach once a year at least. I continued working in the classroom as well as in the research laboratory. It was a very good thing for ten years where I didn ' t have to worry about my salary. The university gained because they didn't have to pay my salary. And since Dr. Paretsky did not hire anyone to take my place in teaching, the university was able to save that money because I said I would teach. Q: What was your research interest during this time? A: My research after my postdoctoral training, where I got my introduction to this field by Leon Campbell. He introduced me to these very interesting organisms, bacteria that really had ( nothing to do with medical microbiology but were of interest in ecology . They are organisms that you find at the sulfer springs, those that give you that smell that's called H2 S, hydrogen sulfide. This chemical is produced by bacteria. These bacteria utilize sulfate and reduce it to H2 S. organisms are called the sulfate-reducing bacteria . These These are those organisms that do not grow in the presence of air . must have what we call anaerobic conditions. conditions they - produce this gas . They They Under these were a very fascinating group of organisms because not too much was known, and so I got involved in this and decided this is what I want to study for the rest of my career. And so I brought this problem back with Dr. Campbell ' s permission to Kansas. 13 The other scientists in the building didn't appreciate i t because when I worked with this the smell would permeate through the whole building. They were calling it Akagi's outhouse. worked with this organism in Snow Hall and old Haworth . I I got a lot of grant money for this, so I was well supported during my tenure as a faculty member at KU. Q: Did you have publications? A: Oh , yes. You had to publish to keep getting these grants . RCDA, the Research Career Development Award, made i t possible for me to spend a lot of time in the research laboratory instead of the classroom. The classroom work was minimal compared to what I would have done. more time in research. and produced papers. were fortunate So I was able to spend I had very good students who worked You had to. Even today you have to. We in producing and publishing papers and we continued to get these grants. We got grants from the NIH, the Public Health Service, the National Science Foundation. NASA was interested in our problem, and so we got grants from various sources. I was on the editorial board for The Journal of Bacteriology, which was the main journal of the American Society for Microbiology. Because of that, I was able to keep up with a lot of publications. you saw a lot of papers. Q: Did you ever write a book? A: No, I didn't. book. Being on the editorial board, So that helped me. I didn't want to take the time to ever write a I contributed to three books. 14 People who were writing them would say, "Would you write a chapter?" do that but I won't write a book . So I For sure I can was able to write chapters and the last book is coming out this year. So it was very nice that I was able to finish my career with a chapter. Q: I guess I forgot to ask you about your children. They were born here in Lawrence, I suppose. A: I have two boys, one born in 1961 and the second one was born in 1963. The older one is now 34 going on 35. unmarried, unfortunately. married yet . I Both are can't talk them into getting The older one is with a government agency. He works for the Drug Enforcement Agency, what they call a DEA agent. He is in the Dominican Republic at this time working on various aspects of drug trafficking. Tempe working in real estate. The younger one is in They are both fine and I hear from them from time to time. Q: You were at KU in the late '60s and yearly '70s when there were so many problems here . Did that affect you or your department? A: No, not really. The only time that we were really involved during that period of unrest was when everyone in New Haworth had to watch guard at night. Remember that? Q: Quite a few people have mentioned that. A: We had to stroll the hallways and stay all night because the bomb went off in Summerfield right by the computer . So we were on guard. There were a That's the only time I was involved. few marches but I never took part in them. 15 These marches occurred and some faculty members were involved in these marches in the 1960's. That was a time when I was able to spend an awful lot of time in my research. Q: I assume you didn't have administrative responsibilities, since your major area was research. A: None until 1976. I was When Dr. Paretsky stepped down as chairman appointed as the chairman . against my will, really. I became the chairman I didn't really want it, but at the same time I said every person should try it once, so I said, "All right. I'll try it." So I was chairman from 1976 to 1985, when I just said, "I can't take it any more." died in 1982. My wife I was going to resign then, but at that time KU was undergoing some real severe budget cuts and I thought, "I can't let that stop me at this time . " said, "I'll see this through." So I didn't resign and I stayed on until the budget situation stabilized and then I said, "Now I can resign." I stepped down as chair in 1985 and then in 1989 I was called back to become acting chair from 1989 to 1991. I figured that the only way I could get out of that was to go on sabbatical, so I went on sabbatical . Since then I've been out of the chair. Q: Do you remember anything specific that happened while you were chair? What was going on in the department while you were chairman? A: There were a lot of challenges at that time . The first nine years to were not bad, trying 16 to learn how chair the department. department I The most difficult part of chairing the found out was treating everyone equally fair. It's very difficult to do. Q: You mean merit pay and things like that. A: That's right. Even though you like some faculty member and you want to give that faculty member a good raise, if that faculty member did not produce, according to the criteria that you put down, raise . then you cannot give that faculty member a And some faculty member that you don't care for as much would get the bigger raise. had to do it. It was the only way. You I have lost some close friends because of that, but it was the only way I could think of doing it. eventually those friends realized that. about the whole thing. I think At least I was honest At least my conscience was clear. But that, I think, is a very difficult thing for any chair to do. And some people would come and ask you for a raise and you just could not, even though the raises were not that much and you would like to give it to them. It's very difficult because if you put down the set of criteria that you say you're going to use for raises, you've got to stick to it. Q: The budget cuts must have been very difficult too. A: The budget cuts were difficult. I tried to let the faculty decide what to do, but sometimes that didn't work out either . Sometimes they had some bad advice. own intuition And I should have used my in solving these cuts. learning process. But it was a good At least I can tell the chairmen now when 17 they would come to me, like the present chair , to ask me for ( advice, at least I was able to give that person some advice what not to do anyway, mistakes I made. It was a good experience, but something I didn't want in the first place. But I learned . Q: You were on university committees, I suppose. A: Yes, I time, was on quite a few university committees during my like Promotion and Tenure, the College Committee on Faculty Appointments, Promotion and Tenure. a while . I was on that for I was on Biomedical Research Grant Committee, The University General Research Grant, a committee on the budget for the College, a member of search committees for chairmen of various departments. ( that I was on. about. Writing Across the Curriculum committee I still don't know what that committee was all The steering committee for establishing the School of Religion in the College. or not. I don't know whether I regret that I was in charge of getting the School of Religion into the College. people serve on. There were various committees that many At the national level the University of Hawaii asked me to teach a course one time, and I was able to do that. I was a member of various panels for NSF programs, for postdoctoral programs. Editorial member and site visit member for the Department of Energy. various other publications. And I reviewed work for I was a member of panels for the Department of Energy and whatever grants they would be giving out, the usual things that I'm sure most people are involved 18 with . Q: You mentioned that you went on a sabbatical. just one? A: Where did you go and what did you do? The first one was Hawaii. Did you have in 1981. I went to the University of They invited me to teach and then I made some friends there while I was there. The person who was there in the biochemistry department was doing some work that I wanted to do in my laboratory. As a matter of fact, he contacted me and we had a collaborative problem going on, together with another person down in biochemistry, two people, Dr. Hersh, Dr. Hines, and I all collaborated with that person in Hawaii, because he was doing all the work that we didn't know how to do. So we sent him all the materials and he was doing the work there . Q: Was this the University of Hawaii? A: Yes. And so I decided to take a sabbatical in his laboratory to learn that particular technique. was there from August on . That was in 1981. But that was the year my wife became sick and she died in January of 1982. called me back in December of 1981. short at that time. and my chair. And I So the doctor So my sabbatical was cut So I came back and went back to teaching Then I had another sabbatical in 1991. that to get out of the acting chair position. I I took went to Germany. Q: That must have been interesting. A: Very interesting. who got his Ph.D. I took it in the laboratory of my student with me and went to a 19 very well-known biochemist and from there established himself as a very good up and coming young microbiologist. The German university saw this, so they hired him to become a professor. So he was now the big shot professor there and I said, "I'll go over there and do a sabbatical with him." Q: What university was that? A: The University of Bayreuth. I wanted to go back to Germany because I was invited there 10 years earlier in 1980 with an international conference, worked on some of the things I had been doing in my laboratory. expenses paid, Germany. so I And so they invited me, had a free vacation there. I all enjoyed My younger brother was in Germany for 30 years. He married a German girl and he was teaching American dependents in Munich, teaching in an American school. So he was there, and every time I went to Germany I would go see him. He took me around everywhere and introduced me to things. I love Germany and that's the reason why I decided I would like to go back to Germany for a sabbatical in 1991. It was a good opportunity because my student was a professor there. Q: You belong to professional organizations, I suppose. A: Yes, three main ones are the American Chemical Society, because I always enjoyed chemistry, the American Society for Microbiology, and the American Society for Biochemistry and Microbiology. Q: Did you hold offices i n any of these organizations? A: No, I did not. The only office was at the regional level . 20 The American Society for Microbiology is made up of various regions in the United States and we all have our own group, like the Big Eight. branch of So you would have the Missouri Valley the American Society for president of that in 1972 . Microbiology. I And we all had to take turns. didn't become part of committees on the national level. just takes too much time away from your research. was my main interest. was I It Research That's the reason why most people come to universities, so they can do the research. Being hired for teaching is a way of getting to research. Q: You mentioned one former student who became a professor in Germany. Are there any other outstanding former students you'd like to mention? A: Yes, there are quite a laboratory. few students that went through my One very bright student I had was from Korea. He got his Ph.D. and did some very good work and went from here and got involved in research and somehow got involved with a person who wanted to send him to medical school. In his postdoctoral years he decided to go to medical school and now is a very good infectious disease person at Temple University. I got another student from Korea who came to my laboratory about 15 years later and he said that that first student, whose name was Bing Suh ... He said Dr. Suh was very well known in Korea and is an example of what a person can accomplish in America. He said it was very difficult for him to realize that he was in the very same laboratory that Dr. Suh came 21 from. And that one, named Jay Kim, got his degree and now he's chairman at one of the Korean universities. I had a student from Iran who got his degree and is back in Iran-. He's chairman of microbiology at one of there. the universities Then Harold Drake is a professor in Germany. Q: Oh, he was an American who became a professor in Germany. A: Oh, yes. accent. He was from Kansas. He speaks German with a Kansas That was the amazing thing about him, because Germans tend to hire Germans. But he was just a plain old Kansan and made a big name and they hired him. which he's very good at now. summer after I retired. doing very well. He didn't know German, I was just over there this past I went out to visit him again. There are others. Tom Novitsky is CEO of a company in Massachusetts just outside of Boston, company in the world on a He's a leading certain analytical method they discovered, how to detect certain bacteria in crabs. It's become very important now medically because in people who have various infections, one of the bad things that can happen is what they call septic shock, the bacterial product going through your whole body and can cause death very easily. Doctors are very concerned about this condition. Well, this Tom Novitsky's company isolated a factor from what they call the horseshoe crab out there in the ocean. This component can detect very minute amounts of this toxic substance. everywhere in the world. Now it's He sends me postcards from virtually every part of the world, Russia, Japan, France, England, you 22 ( name it, he's been there because he had to go help set up a laboratory or set up a business there. he's now CEO there. Chan. So he's a big shot and My brightest student was a woman, May She came from Taiwan and she is now working for the Navy in China Lake, California, and she was so good that she has been put up many times as woman of the year for that section. There was some university unit right outside of Stanford . They offered her essentially an endowed chair, and so she called and asked if she should take it. ahead. Take it." I said, "Go But she didn't take it because she was with her husband, and her husband did not get any job over there. Her husband was a big shot at China Lake, so she decided to bypass it. But she was the brightest student I ever had. But the most interesting case about a student that was not mine but somehow came to KU ... I used to tell this to my classes whenever we'd come to this part of the course. was Satoshi Mizutani. years, I was research there Japan. in Cleveland and I was and another postdoctoral doing postdoctoral student was And Sam and I came to Kansas. from were very All of us post docs were very close. Sam went to Manitoba. I Going back now to my postdoctoral His name was Sam Suzuki. close friends. The person's Anyway, He got a job in Manitoba, Canada, and Satoshi Mizutani was a student from Japan looking for a place to go, and he thought he would be more comfortable if the person he went to was Japanese. So he heard of Sam Suzuki, so he wrote to Sam Suzuki and said he'd 23 ( like to go there, but Sam said right now the department can't use any new students. to, Jim Akagi. But I have a friend in Kansas to write And Satoshi wrote to me and I was on the admissions committee at that time and he was just another one of hundreds that was coming in. So I said, "Why don't you write to me later on in the year and I' 11 know more about it." And I thought that would be the end of it. forget. Well, he didn't He wrote me at the end of the year and since we had some money, I said, "Okay, why don't you come over. give you a research assistantship." a very good student. We can He came over and he was He was working with another person but the interesting thing is that after he got his Ph.D. he was looking for a postdoctoral position. Dave Paretsky had just come back from Wisconsin from his sabbatical and he said, "There's a person up there named Howard Timmons who could use a post doc." He was applying to everywhere and one of the places he was applying to was Howard Timmons and Timmons invited him to come work with him. interesting person. Timmons was a very He was for five to ten years saying that the genetic material in this virus he was working with was RNA . Now everyone knows that DNA is genetic material and RNA is just another part of nucleic acid, different. similar to DNA but And everyone said, "You're crazy." fact they were laughing at him and saying, As a matter of "Who would ever think that RNA could be genetic material when everyone knows and it has been established that DNA is the genetic material." 24 Now Satoshi Mizutani goes to Timmons' lab as a postdoc . And pretty soon Satoshi is writing back to us saying that some very interesting thing will be reported at the Houston meeting and Howard Timmons would report it. And what Howard Timmons reported was he got unequivocal proof that RNA could also be the genetic material in this virus as Satoshi Mizutani found in his laboratory. Satoshi did all biochemistry. And Timmons got the Nobel Prize for it. the work because Timmons did not know He just had this circumstantial evidence that RNA was involved. But Satoshi went up there and because we trained our graduate students in biochemistry he was able to do the biochemistry that finally allowed Timmons to get the Nobel Prize. And so we are very proud of that. But there are many good students that went through my laboratory. I was proud of many of them. Q: Were you involved in community activities in Lawrence? A: Only when the kids were growing up. One almost had to. I was happy to do it, the Boy Scouts and the Cub Scouts as well as other things. demonstrate to We used to travel to various grade schools to them what microbiology is . We'd bring a microscope and these other things to classes where someone knew someone who knew my sons. personal invitation. It would be more or less a We used to advertise to teachers that if you want us to come by we will be happy to teach for one hour and give a demonstration of microbiology. Q: That would be interesting to kids. 25 A: We'd let them look in a microscope and see why they shouldn't put coins in their mouths. of fun. I We used to do that. It was a lot think some of that is still being done by the department. Q: Do you have continuing involvement with KU now that you've retired? A: Well, with the department I ' m still a member of some of the students' Ph.D. committees. Other than that, I told them let me at least for this first year--I just started my retirement three months ago--let me just enjoy my retirement and not have anything to do with academics . After that first year or two if I'm still here in Lawrence then I'll reconsider. But right now I'm not interested in doing anything for the university. I went to Germany, I went to Seattle a couple of times and I've been taking these trips. Q: That's what I was going to ask you. What are you going to do now that you've retired? A: Well, I'm going to do a lot of things that I've wanted to do. Our whole family has always been musically inclined. Q: Do you play a musical instrument? A: I'm the only one that does not have any music . like to . I am ready to set up piano lessons. But I would My older sister played the piano and my younger brother was a music teacher. So I would like to take piano lessons, which I will. going to start as soon as I Other things like bowling, 26 I'm get my trips out of the way. I want to do bowling . I love cooking. those . If there are cooking classes around, I want to take Cooking always fascinates me. Q: Do you do Japanese style cooking? A: Oh, yes. I can cook Japanese. was an undergraduate. I I used to cook a lot when I learned from my mother. And I've been learning from my sisters and whoever would teach me anything. students I A very close friend of mine, when we were graduate lived with Dr. students here together. he is Italian. So I Consigli from K-State. We were Well, as you can guess from his name, learned a lot of Italian cooking from him, which I still use, and Chinese cooking, which I learned. Cookbooks are one of my big things that I love to look at and learn from anyone. Not baking but cooking. And I'm going to get back to bowling and horseback riding, which I used to do a long time ago. If I run out of things I even am planning to go to bartenders' school, not to do that as a living, but just because I am curious. Q: Oh, so you'll know how to mix your own drinks. A: I was on the other side of the bar for all these years and I'd like to see what it is to be on the other side . I understand they have a bartenders' academy in Kansas City. So eventually I would like satisfaction. Q: to take that course, just for my own Travel in the meantime. What is your assessment of KU, especially your department, past, present, hopes for the future, that kind of thing? A: Well, the department was very, very good. 27 We had a very good reputation nationally and internationally. its heyday. I was involved in And then gradually the budget problems began and then during my tenure as chair we were hiring people, good young people. I guess they were too good, the people we hired. Q: You mean they leave? A: They left, yes. Other places wanted them too and we couldn't compete because KU doesn't pay very well. to lose people. And so we started As our department started going down and people were leaving, we were having a difficult time filling their positions, getting permission to fill their positions. And the strategy of the dean's office at that time was this. In 1968 because of various departments, biological sciences department getting kind of weak, very little enrollment. One way the biological science department could survive is to go in as a division, proposed. biological science division, which they So they called a meeting of all the biological sciences and said, "If you go under the umbrella of this division, you will be protected. The regents cannot look at you and say you are weak, we are going to get rid of you . " But microbiology was very strong. publishing. We all had grants. We were We said we didn't want to go into the division . And the other biological science division was the department of radiation and biophysics. go in. Q: They said they did not want to So every other department went in. And that became systematics and ecology? 28 A: That was one department, systematics and ecology. Physiology and cell biology was another department. Entomology was a department, botany was another department . Biochemistry was another department. All of them went into the division. Microbiology was an island. Biophysics was an island but eventually into they got pushed microbiology and the division . it. So then it was And every dean that came up, even when I was the chair said, "How come you're not in the division?" We didn't feel like we were weak. up on our own. We don't need the di vision. the are way we and being was as big as the division's. academically, Our departmental budget Now that is not going to go unnoticed by people in the division. gets so much money?" We are very happy successful, researchwise, grantwise, everything. We could stand "How come microbiology They just kept going to the dean until finally their budget started going up to where it should have been, because their budget was pretty low. said, "Come into the division." We don't want to." It's not very good." But they always We said, "We don't have to. And many people said, "Don't come in. our friends used to tell us that. But anyway, from the dean's standpoint it would be much easier to deal with one person, the head of all t h e division, rather than one person plus microbiology. And so they always tried to get us involved and they said they would never force us to go in unless we ask to go in. about that. So the deans were very good Well, now we're coming up to 1989, etc . 29 People in the dean's office as people in our department moved said, "We don't have enough money to give you to hire someone new." People in the division were getting money to rehire vacancies. And so another person from our department would leave and they would say, "We don't have any money." So from a full staff of 10 we finally came down to five, half. were getting pretty small. that with five people. Now we And not only that, our enrollment is going up more than when we had 10. And we are doing all Finally, the dean said, "You've got to come into the division. You have to come in or, you know, there are various consequences." forced. any So we were more or less So we said, "Give us three years to phase in." In other words, we'll go into the division but let us still get our own budget. wanted our money. They (the division) wanted our budget, they That's what they wanted. So the dean said, okay, for three years we can handle our own budget, although we are in the div ision. of fact. This is the third year, as a matter So we came into the di v ision t wo year s slowly are phasing in. ago and And as soon as we joined the division, all of sudden we got permission to hire a lot of people. personally don't feel that was right . I The deans knew we were strong and they deliberately wanted to make us weak so they could tell us to go into the division. Because of that we are in the division now and I don't know how they are now. glad I am not in the department right now because I I'm don't think the future of microbiology is going to be that good. 30 And yet it is microbiology that is going to be one of the more important fields in the medical sciences. the genetic ... all the things on DNA, evidence. You can think of the O.J. Simpson DNA All that started from microbiology . science of that began in microbiology. The whole This whole thing on the immune response, the HIV, that's all microbiology. The viruses are all microbiology, and nutrition, where we got all our information on vitamins started with microbiology. and of these things Don't ever eat any hamburger We tell our students that and the salmonella problem that you have to be careful with poultry. There are so many aspects of heal th that involve microbiology. microbiology is still going to be one of the big, fields. all And now we are very well aware of the E Coli thing and hamburgers. that's pink. all So important The biggest problem hasn't even come yet, and that's the use of antibiotics. The bacteria become so resistant to antibiotics that pretty soon from an ordinary scratch it can turn into septicemia, process. There is antibiotics will help. I that is to say the whole infectious nothing you can do about it. No From a simple infection you'll die. mean it can get to that point. Prewar, we call it pre- antibiotic era or pre World War II. when there were no antibiotics. I grew up in a period And I remember a friend of mine who got an earache and then a few days later he was dead. No antibiotics. You'd get a scratch and then it would become what they called blood poisoning at that time, and you could 31 die from it. There was nothing you could do about it because ( we didn't know what antibiotics were at that time. remember those times. I still And we are entering that period again because doctors are prescribing antibiotics for people who really don't need them. And people are asking for antibiotics when they don't need them and doctors will give them to them because they don't want to lose their patients. These people are just ruining this whole process. Q: So you mean they will have to discover new antibiotics. A: Well, yes. But in 1979 the Surgeon General made the statement that we don't have to worry about infectious diseases any more. Antibiotics will take care of concentrate on heart disease, everything. Let's let's concentrate on cancer, let's concentrate on this but don't worry about infectious diseases, bacterial diseases. That was one of the more stupid remarks to make because from then on until 1991 only one new antibiotic was developed by a pharmaceutical company. there were only three. In 1993 back to one and in 1994 about three, when there used to be 10, year. In 1992 20 new antibiotics every But now in the past from 1991 to 1994 not even 10 new antibiotics came out on the market, which shows they're not doing any new research in new antibiotics. starting now, but we are a I think they're few years behind now, because they're realizing now that the ordinary, common bacteria that causes pimples, causes boils, now they are causing massive infection and killing people. 32 Before they used to just treat them with penicillin. They can't do it any more. And some of them, when you go in a hospital, 50 percent of every case of staph, staphylococcal infection is due to an organism that is resistant to every antibiotic except one, and they are trying to hide that antibiotic from this organism until they have to use it. If that organism gets resistant to that one antibiotic, which it will, then there is nothing you can do about it . right now. again. And there are people dying from a common infection And these are some of the problems, microbiology One of things about KU is that everyone was trying to protect their own field, which is good. This is human nature. People in the dean's office--there are so many biologists in there--they are trying to protect and help people in their particular field of interest and not help microbiology as much, when they should. So microbiology at this time will make a comeback, I think. The younger people that we've hired are very good. I am really impressed with the four younger people that we have hired in the past three years. very good. I They ar_e just hope that they won't be ruined, not by microbiology but by certain administrativ e decisions. But if they are allowed to do as they want to do, I think these four plus maybe one more, my replacement, might help get the microbiology department back to the lev el where we were once a very well-respected department. I'm just hoping that this will be the case . Q: Well, I think that's about it. 33 Is there a nyt h ing I didn, t ask you that I should have or that you want to add? A: The 34 years that I spent at KU were very happy ones. really enjoyed every year. It went so fast. It was so quick that it is hard to believe that I was here for 34 years . has to do with when you're having fun, quickly. I It time goes by very It was all fun, really, the teaching as well as the research . Not only that, but the community of Lawrence is one that one rarely finds throughout the United States. I will have to admit that if the right place becomes available, I may go back to the Seattle area, back to my roots. I have a lot of good friends there from camp . Q: Oh, you mean they went back. A: Most of them did. Some of them I haven't seen in 40 or 50 years, but we still keep in contact. them. I would like to see It would be a very difficult decision if I were to find a place back there. There is ambivalence there . Or maybe if my son--my older son lov es Lawrence and keeps coming back here--I may make a deal with him. You can buy this house. Let me go back to Seattle." could come b a ck and forth . place . "Do y ou want this house? Then I But Lawrence has been a v e ry nic e If at all possible, I'd like to stay here. 34