—. 2 (a) Contributes to crimes of violence, poverty, disease, and disor~ ganization of homes. Control (a) Federal: Laws--Food & Drug Act, Harrison Law. le Organization: U. S. Public Health Service, Anti-Narcotic League. (b) International: League of Nations, Health Section (c) State: Departments of Health, Hospitals and Clinics. Tobecco The use of tobacco should be considered from the standpoint of its effects as: {a) Habit forming substance {b) An injurious substance (c) In its relation to efficiency Composition of Tobacco While tobacco as used is the leaves of the plant nicotiana tabacum, our interest from the standpoint of defensive hygiene is in the active principles in the plant which are possible chemical poisons. Nicotin is the most important of these, In its pure form, it is one of our most powerful, fatal, and rapidly acting poisons. The nicotin content of the various kinds of tobacco vary considerably from 1.3% to 4%, for Havana ani Maryland, to 6% to 8% for Virginia or Kentucky tobacco. Tobacco contains many other substances which give it a characteris= tic flavor. One of them, pyridin, on heating gives rise to substances that are of importence in estimating the physiological effects of tobacco. Two of them are carbon monoxide and furfural. Combustion of Tobacco Our interest lies in understanding what is responsible for its charm and its ill effects. There can be no debate about the serious ef- fects of such a powerful poison as nicotin if used in any but the most minute quantity. It is its effects when taken into the body in such amounts and forms as are present in smoking and chewing tovacco that causes much controversy. The amount of nicotin in the smoke of burning tobacco depends upon the kind ami formof tobacco, and the amount of moisture present. This varies fra 14%, to 35%, in cigarettes, to a much higher percentage in ci- gars and pipes. It is claimed by some investigators that nicotin is practically des- troyed in the process of smoking and that the effects of tobacco are lim ited to the decamposition products resulting from the pyridin. This does not explain the fact that the same physiological effects are pro- duced by chewing tobacco.