[English translation]

Soporific of several kinds suited to the person and, for the most part, tested.
Take 3 drams each of lilies, lettuce seeds, bishop's weed, henbane and black poppy and 2 drams each of opium and poison hemlock. Everything should be cut coarsely and put all these into two lb. of Greek wine or the best malvasia and let it infuse for 24 hours. Then distill it in the glass still with a slow fire and save the water which will be perfect to make one sleep. In the evening when one goes to sleep, give 3 drams to drink and soon the person will be sleeping and will sleep all night, longer or less according to the amount that you give to drink. When you want him to awaken, bathe the wrists and the nostrils of the nose with strong vinegar and he will wake up at once without surprise and not at all ill. This has been tested. Take what you want from the following.

Another sedative, a little more active.
Take 2 ounces each of thorn apple, Theban opium and henbane, 1 dram each of orpine and black and white poppies, 3 ounces each of lettuce seeds and purslane seeds and water made of dodder, from those bad seeds that grow in the grain when it begins to mature and then a water is made from them in the still. All the above things should be softened or break them coarsely. Then distill everything in the glass still on a slow fire. Save the distillation as a thing very dear, especially to cause sleep. Give 2 drams to drink in the evening in half a glass of wine when one goes to sleep and he will sleep 6 or even 8 hours without awakening. Then wash the wrists with strong vinegar and at once he will awaken.
If you do not want it as a water, make it as a powder and it will have the same effect. That is, you can make this composition as above and when you have put in the water, let it stay until it dries in an airy place, not in the sun. When it is dry, make very fine powder and save it in a little sack of leather and keep it in a dry place. When you want to use this powder, give 2 drams and not more, mixed with other spices. You can give it on foods as you wish and it will not be bad if it is made with other spices. Very soon sleep will come and one will not sleep less than 6 hours. Also one may be awakened by bathing the wrists and the nose with vinegar so that the stupor will pass away quickly and he will be as before and will not think about being sleepy. This is used for one who cannot sleep. This is a good, tested secret.
If you want to use a shorter method, take this composition in whatever amount you wish and bind it in a fine linen cloth. Allow it to boil a while, putting it in soup or broth or put it in wine or water and let it stay for a piece. Then extract it and press it well over the liquid. When you want to cause sleep, use it and it will act the same as above.

Another sedative.
Take 9 ounces of good, odoriferous wine and put it in a bottle. Then take 2 drams each of lilies, henbane, black poppy, opium, ordinary salt, sedge, aloe wood, nutmeg and bedstraw and 4 drams each of lettuce seed and white poppy, all finely ground. Put them in the bottle in the wine and stopper it well and put it to extract in a bath for 9 days. Then remove the wine carefully so that the sediment is not disturbed and leave it to clarify and save it in the bottle. When you want to use it, put 3 drops in wine or in some other material and it will cause sleep. Note that when you want to awaken someone from sleep, it is necessary to wash the nostrils with vinegar and put some in the mouth.

Another, a good soporific to make everyone in the house sleep.
First write these words on unused parchment and put them over the door. These are the words, viz. '
Somnifer, somita, sandior, lapus, qui placidus est, somnolentus est.'
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[Italian transcript]

Sonifero de piu sorte et secundo persone et la magior parte aprobate.
Rx. giglii, seme di latucha, ameos, iusquiamo, papaveris nigri, ana drame iij, oppi, seminum cicute, ana drame ij, et ogni cosa sia rotto di grosso. Et tutte le predette polvere li metterai in doi lb. de vino greco overo optima malvasia et lassele stare infussione per 24 ore. Poi le destillerai al lambicco di vetro con foco lento et serberai la ditta acqua la quale sara perfetta per fare dormir. Et ne darai la sera quando va a dormire a bere drame iij e presto si dormentera et dormira tutta la notte e piu e meno secundo la quantita che tu ne farai a bere. Et quando lo vorai isvegiare li bagnerai li polsi e le nara del naso con aceto forte e subito si suegera e senza sbalordimento et niente li fara male. E questo egli e statto aprobato. Et piglia qual tu voi di seguenti.
Item, un altro sonifero um poco galliardo.
Rx. noce metela, oppio tebaico, iusquiamo, ana onze ij, fava inversa, papavero nigro e bianco, ana drama j, semente di latugha e di porcellana, ana onze iij, e acqua fatta de loii di quella semente cativa che nasse inel grano quando il se cominza amaturare allora se ne fa acqua al lambico. Et tanta ne piglia quanto che tutte le predette cose possano stare amoia et tutte siano rotte grossamente. Poi destillerai ogni cosa al lambico di vetro con lento foco. Et la distillatione tu la serberai per cosa molto accara massime per fare dormire. Et dane a bere la sera drame ij in mezo bichiere di vino quando va a dormire et dormira 6 anche 8 ore continue che mai non si suegera. Poi bagna li polsi con aceto forte e presto si suegera.
Et se tu non la voi in acqua, falla im polvere e ti fara quelo effetto medemo, cioe farai quella composicione che tu ai fatta disopra et quando tu li ai messo drento l’acqua, lassela stare cosi tanto che la si secchi in loco arioso e non al sole. Et quando la sera secca, fane polvere sutilissima et conservela in sachetto di sovatto e stia in loco assutto. Et ne potrai dare dela ditta polvere drame ij e non piu, mescolata con altre speciarie, et ne potrai dare sopra ale vivande come a te parera et non potra far male perche sarano preparate con altre specie. Et presto presto li verra il sonno et manco di 6 ore non dormira. Etiam che dassi si suegia, bagnali purre li polsi, el naso con aceto acio che piu presto li passa via quello balordimento. Et sia chi si vole et piu non pensera a quella cosa. E questo si fa a chi a perso il sonno. E de bel secreto, probato.
Et volendola usare a un altro modo piu breve, piglierai dela ditta compositione quella quantita che a te parera et leghela in una pezeta de lino sutila et ponila per um pezo a bolire drento alla sua minestra o brodo overo mettila in vino o acqua et lassela stare um pezo e cavatelo e premetilo bene sopra ci[b]o et usela a dare quando vai a dormire et fara il simile ut supra.
Item. Un altro soniffero.
Rx. vini fini hodorifferi onze viiij et pone in ampula. Posteam, Rx. lilii, iusquiami, papaveris nigri, opii, salis comunis, ciperis, legni aloes, nucis moschate, gallie muschate, ana drame ij, seminis latuce, papaveris albi, ana drame iiij, omnia terrantur subtiliter et pone dictam ampullam in dicto vino quam obturat fortiter et pone ad digerendum in balneum per 9 dies. Posteam accipe et evacua vinum suaviter ita gude fex non turbetur et dimitte clarificari et serva in ampullam et quando volueris eo uti pone tres guttas in vino ut in alio aliquo subicto et faciet dormire. E nota quidem quando volueris exicitare dormientem oportet lavare nares cum aceto et mitere in ore.
Item. Un altro soniffero bello et fara dormire tutti quelli di casa.
Prima scrive questi nomi in carta vergine et poneli sopra alla porta, et questi sono i nomi, vz. ‘Sompifer, somita, sandior, lapus, q[ui] p[lacidus] e[st], s[omnolentus] e[st].’