University Daily Kansan
Friday, March 3, 1978
3
Profs test cancer drug
By ROB HAGAN
Staff Writer
A new drug to fight cancer is being tested at the University of Kansas.
at the University of California and Arnold Reprint associate professor of pharmacy, and Leslie Liebeno, Leavenworth, NC1 155 78, to see whether it maintains its chemical properties under certain conditions. NCI 135 758 is the number that the National Cancer Institute assigned to the drug.
"We are trying to determine the stability of the drug under normal room conditions," said Terry O'Brien, a physician.
Under certain conditions, Repta said, drugs can lose their potency.
A chemical reaction, he said, and the drug that was started with could end up a totally different one.
If conditions change a drug, Repta said, a physician does not know whether he is giving a patient the correct drug or a different one, which could be toxic to the
REPTA AND LIEBAN are trying to learn REPTA and LIEBAN are trying to learn what conditions a will change its count.
"If you know what happens to the drug,
you can take protective measures." Repta said.
sss
light, water and air can produce chemical reactions in drugs and change their compositions. If a drug loses 10 percent of its composition it has to be discr
deer.
NCI 135 758, which has never been tested on humans, is a new drug, Repta said, that the cancer institute wants researched.
"The drug won't be used on humans"
Reptilia uses our research is completed
and if it works.
to turn out in a liquid, he said, changes into hydrochloric acid in a certain length of time.
“THIS IS NO problem,” he said, “because the dosage is so small it wouldn't do any damage.”
If the drug passes the tests at KU, it will go back to the cancer institute for treatment on animals. If that is successes, Repa said, the drug will be tried on terminal cancer patients.
All the terminal cancer patients have to give their consent to use the new drug. That phase of the experiment would determine whether the drug was harmful to the patients.
The research at KU is funded by the National Cancer Institute. Since 1972 Repta has received $700,000 for his drug research.
In that time he has studied 25 drugs' stability and solubility. Some of the drugs are now being used in clinics across the country.
SOME DRUGS that already have been found to be stable are being researched further by Repta. These are aimed at the treatment of reptile bites, occurs in the testes, testes, neck and head.
ovaries, testes, breast, or kidneys. The solid types of cancer, he said, are harder to treat than blood cancers, such as leukemia or Hodgkin's disease.
However, Repta cautions people about thinking that one drug will cure cancer.
"I don't think people should concentrate on any one drug as a cure for cancer," Repta said. "What people are looking for is a cure. I won't be that optimistic because there have been so many drugs that have failed.
"The best we could hope for the drug we are testing is have it work by itself or with another drug for the treatment of a certain type of cancer."
Operas inspire journeys
Bv SUSAN WOODARD
Staff Writer
It wasn't the first time Madame Ruth Michaelis traveled hundreds of miles for the sake of opera. In 1966 it took her from Munich and the Bavarian State Opera to Istanbul where she helped Turkish State Opera in 1961 it took Madame Barbara, Calif., where she taught and performed at the Music Academy of the West.
AGDAIR
on week, Michaela left her home in sunny Santa Barbara to direct the University of Kansas production of the opera, "Falstaff."
opBraze, all her旅程, Michaelis' recent work in California hasn't allowed her much time to see the United States. This is the first time she has visited the Midwest, she said, and the first time she has seen snow in 17 years.
MICHAELI WAS born in 1909 in a part of Germany that is now Poland. After World War I, her brother moved to move to Australia, where years she worked in a bank to help make deals meet.
"It was the furthest possible thing from what wanted to say," said I. "I had an agreement with the numbers."
Immediately after World War II, opera was extremely popular in Germany, Michaelis said. She said she used her two complimentary tickets from the Bavarian Opera to trade for things that the inflated currency could not buy.
But the bank job gave Michaelis the money for what she wanted to do—study voice. In 1939, after eight years of study and performance at various municipal operas, Michaelus was made to join the Savannah Opera in Munich. She remained with the opera for 20 seasons.
"NO ONE OBJECTED to the fact that the theaters were one of the first things they made operational after the bombs," she said. "The opera was sold out to a degree that people stood in line all night to get tickets."
In 1956, while she was still with the Bavarian State Opera, the Turkish
government invited Michaelis to Istanbul to help establish a new state opera school. Though the appointment was to be for only nine months, Michaelis spent four years in Istanbul but returned to Munich each summer for the Summer Opera Festival.
"There is a fantastic theater in Turkey," she said. "They are highly talented in theatrics. I saw some gorgeous performances there."
He teaching experiences in Istanbul eventually led Michaelis to accept a teaching position at the University of Southern California.
'AFTER IHAD been teaching in Turkey,
'AFTER IHAD been teaching it to teach and to
have young people around. You can tell
him what you're doing, you heard
before and introduce them to opera.
before I came to me to refire from my position at the Bavarian State Opera and go on a tour of Germany.
"Falstaff" was Verdi's last opera, written when he was 80 years old. It is a comedy with characters taken from Shakespeare's "Merry Wives of Windsor" and "Henry IV."
"Falstaff is not an opera like usual opera, with arias and duets and a little something in between but never a conversation. The tempo is quick—it never rests."
The opera, which opens April 21, will be sung in its original language, Italian. According to George Lawner, professor of ensembles, the last one of his works was Pucerius's "La Boheme" in April 1972. Mozart's "Cossi Fan Tutte" was performed last year in English.
"IT IS IDEAL to have 'Falstaff' in the original," Michaelis said, "though we might not expect everyone in the audience to know Italian and understand it. But music is the great helper. We hope we will be able to convey what we mean and what is going on. Music is an internationally understandable language."
The opera also will be performed in period costumes from the 11th century, the time of Henry I, Michaels said that directors who tried to modernize opera by having performers appear in contemporary dress were violating the wishes of the composer.
"It's nonsense," she said. "If I go to the Louvre in Paris with a big pot of paint and a brush and go to the 'Mona Lisa' and paint her dress green and say that was the way Leonardo really meant it, he had in hand what he me in prison. But that they are doing with some of the great masterpieces in music and nobody forbids them."
LAWNER SAID that Michaelis was selected to direct "Falstaff" by the University Theatre and the School of Fine Arts because of her experience with the opera and her vast experience in staging opera.
opera.
"She is a specialist on this opera, having sung it herself." "Lawyer said," and she is a distinguished director and singer."
Michaela is a mezzo-oprano and she sang over 80 different roles while she was with the Bavarian State Opera. She also performed in various operas in other countries, including opera gave her great variety as a singer.
"The MEZZOS or altos in an opera are always colorful personalities," she said. "The sepranos are always beautiful, mostly blond and blue-eyed, and they are innocent. If they die, they die innocently and everyone is touched.
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"The mezzos are the uncomfortable characters," she said. "They are very interesting. They are either gryphs or forlorn giants. Very, very often they are intrigues."
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