University Daily Kansan, January 17, 1985
NATION AND WORLD
New study changes previous beliefs
Page 1.
Breast lumps may not signal cancer
By United Press International
BOSTON — Women with most types of non-cancerous lumps in their breasts are no more likely to develop cancer than the average woman, but it was previously thought, researchers said in a report released yesterday.
But the risk increases if such non-cancerous lumps are spreading, rising to 11 times normal if the woman has a family history of breast cancer or who has been published in yesterday's New England Journal of Medicine.
"The vast majority of women who undergo benign biopsies are either at no increased risk or have really quite a slight increase in risk," said
William D. Dupont, assistant professor of biostatistics at the Vanderbilt University School of Medicine.
"Only a relatively small proportion of the entire population of people who receive a diagnosis of benign breast cancer is substantial risk of cancer," he said.
The study, conducted by Dupont and other researchers at Vanderbilt, reevaluated 3,303 stored breast samples from women who had lumps removed for analysis. The women were then contacted an average of 17 years later to see if they had developed any kind of cancer.
OF THE WOMEN STUDIED. 68.5 percent had nonproliferative disease, which means there was no evidence of abnormal spreading. These women had no greater risk of cancer than normal.
In the past, most people believed there was a slightly greater chance
of developing breast cancer if a woman had cystic fibrosis, Dupont said.
The condition is also known as benign breast disease or fibrocystic disease. Because more than half of all women have the condition, doctors question whether it should be called abnormal.
Another 26.2 percent of the women studied had proliferative disease without any other abnormalities, and 10 percent were spreading. They had a cancer risk 1.9
times greater than the average woman.
A final 1.7 percent had a mild form of cancer called carcinoma in situ.
Also, 3.6 percent had a condition called atypical hyperplasia, which means the cells were abnormal but not enough so as to be considered cancerous. Women in this category without'a family history of breast cancer were 5.3 times more likely to develop cancer. Those with a family history of breast cancer had a risk of cancer 11 times greater.
Dupont and Dr. David L. Page, a professor of pathology at Vanderbilt, said none of these conditions by themselves, except carcinoma in situ, warrant additional breast surgery.
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