University Daily Kansan / Wednesday. September 19, 1990
9
Device aids in solids analysis
By Amv Zamierowski
Kansan staff writer
Until recently, KU laboratories could analyze only the chemical structures of solutions. But with the development of device, they now can analyze solids.
Before the accessory was installed on a spectrometer in the University of Kansas' Nuclear Magnetic Resonance Laboratory, most samples had been prepared in the form of solutions, said David Van Veer Velde, director of the laboratory.
"Usually we had to dissolve the samples to study them, but sometimes what is interesting about them are properties in the solid state." he said.
Vander Velde said that no other laboratory in Kansas and fewer than 100 in the country had the equipment
to perform solids analysis. He said the equipment would be used for ongoing research projects on campus
The equipment also will be used by FMC Corp. InterX Research Corp. and Oread Laboratories Inc., all of Lawrence, and Marion Dow Laboratories Inc., in Kansas City, Mo. The companies helped finance the purchase of the device, which cost $44,000. The Kansas Technology Enterprise Corp. also provided a research equipment grant.
Kathleen Heppert, research chemist at InterX, said the goal at InterX was to optimize a drug's effect on the body
delivery system." Heppert said. "Our interest is in controlling the release of drugs into the body."
"At InterX, we look at a drug's
Hieppert said some drugs embedded in erodable polymers, which are large molecules that degrade with time.
"We are hoping that with the solid state, we can look at the polymer's interaction with the drug," she said.
KANSAN CLASSIFIED WORK
By understanding this interaction, they can control better the release of drugs in the body, she said.
"Normally, you take a pill and get a big initial dose of the drug along with a side effect," Heppert said. "But we want to devise a system that will be more slowly over time. Then the pill will have to be taken less frequently."
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