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CAMPUS AND AREA
University Dally Kansan, September 7, 1984
Page 7
Professor's article in national magazine
By JULIE MANGAN Staff Reporter
A KU professor soon will see his byline in National Geographic magazine because of his interest in cancer research.
Robert F. Weaver, chairman of the biochemistry department, said his article for the December issue of National Geographic encompassed genetic engineering and the use of monoclonal antibodies.
Weaver's research in genetic engineering, mentioned only a few times in the article, involves cloning
a gene for a toxin called Ricin, which comes from castor beans.
"WE ARE CLONING this gene so we can produce pure Ricin in bacteria." Weaver said. The combination of the toxin and antibodies directed against cancer will kill cancer cells but not healthy cells.
The toxin kills the cancer because an antibody recognizing some protein on the surface of cancer cells will bind only to those cells, he said.
Weaver said his team of nine graduate students, one post-doctoral assistant, two visiting scholars from China and a technician still were researching the toxin-antibody combination. The team is getting results, but not as fast as he would like, he said.
In addition to the Ricin project, which is supported by Eli Lilly and Co., Weaver and his research assistants are examining the control of gene expression in an insect virus.
"We are interested in the way genes turn off and on." Weaver said.
ONE REASON FOR their interest, he said, is that normal cells changing to cancer cells seem to turn new genes on or possibly turn old genes off. The researchers might be able to understand the operation of cells more easily by working on an insect
virus containing 100 genes rather than a human cell with about 100,000 genes.
The article is Weaver's second for National Geographic. His first article, published in September 1976, short piece called "The Cancer Puzzle."
WEAVER WROTE THE genetic engineering article in 1978, but the magazine didn't print it because engineering is hard to illustrate.
The magazine solved the illustration problem by hiring a freelance photographer who is good at illustrating difficult subjects, Weaver said.
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