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Friday, September 7, 1979
University Daily Kansan
Med Center wages cancer war with development of hybrid drug
By TED LICKTEIG
Staff Reporter
In the quest to cure cancer, University of Maryland Medical Center technicians have tried to treat a rare genetic disease dissolve cancer cells, C. C. Cheng, co-director of the Cancer Center, said.
"We start with a drug that has successfully fought cancer before. Then we ask why it worked and try to improve on it with another drug," he said.
The center is working on a chemical called dihydroxyanisoumbistilfuqe duque, or DHAQ, which was patterned after the proven cancer-fighter, adriamycin.
Adriamycin, a proven anti-cancer drug, and elements from other known cancer-fighting drugs, were combined to form DHAQ, Cheng said.
He said that the center had been working on DHAQ for three years and he thought that if it did go on the open market, it would be given intravenously.
HE HAD NO guess about the drug's chance of eventually being used in the cancer fight, and said the center chose to apply chemical it appeared to be a promising remedy.
"You have to wait at least five years to see if there is a recurrence (of cancer) to treat."
say that it is a proven anti-cancer medicine,"Cheng said.
Cancer, which develops in one out of every four Americans, usually is attacked with a combination of surgery, radiology and chemotherapy. Cheng said, rather than with one method.
"In dealing with chemotherapy drugs, we must design the drug after what has worked for other investigators," he said.
Researchers read other investigative reports to make sure the center is not duplicating someone else's work and to learn from them, Cheng said.
"We have to determine why a particular chemical is active against a particular type of cancer, then locate a promising area for synthetic research," Cheng said.
HE SAID THE center would be fortunate if it could develop a chemical to combat three or four types of cancer of the more than 100 types known.
"Then we must devise an efficient and practical synthesis with another compound so that the drug can be administered."
That other compound either would be water for intravenous injection or a solid for oral consumption, he said.
Then, an adequate quantity of the drug must be produced, for testing on laboratory
animals, followed by analysis of the test results and approval of the drug by the Food and Drug Administration for further research.
IF POSITIVE results continue, the drug is released to the National Cancer Institute for isolated use at selected hospitals.
Cheng said that nationwide, 20 to 30 drugs would be developed in a similar way, with about five or six actually used by doctors to combat cancer.
After a drug passes laboratory tests, the drug is used against a specific type of tumor in a laboratory animal, he said.
After tests by the FDA to determine whether the drug is poisonous in other environments, a dosage must be approved by the National Cancer Institute, Cheng said.
Although many pharmaceutical firms think there are unnecessary delays in the approval process, it is essential to be careful, he said.
"The pharmaceuticals don't like to see delays because they have money at stake, but if everybody is doing his job, we have no support with FDA's procedure," he said.
Barth Hoogstraten, co-director of the Cancer Center, warned against getting the public excited about cancer-eruing drugs.
"We're not reporting on this type of thing until we are certain that it works," he said.
Union photos depict Midwest
By AMY HOLLOWELL
Bill Kipp left his Boston home in 1977 and came to the University of Kansas to study photograph in a man whose work he built in New York's Museum of Modern Art.
Staff Renarter
Two years and a master's degree later, Kipp is the organizer of a Kansas Union Gallery show titled "Five Photographers of the Midwest." Both he and the man who taught him here, Earl Iverson, assistant professor of design, contributed to the show.
The show, which ends Saturday, is a collection of photographs depicting people, land, architecture and horses of the mid-20th century. The photographers focused on one of the subjects.
Kipp said he selected the five artists because he had known them for about five years and because each had some connection with KU.
LARRY SHWARM, a photographer for the Spencer Art Museum, became involved with the exhibit because, he said.
"the photography circle at KU is small, so we all know each other."
Shwarm did all the landscape pictures in the show.
"I took the traditional land in a non-traditional viewpoint," he said, "reducing the three-dimensionality and flattening out it by taking "a same two-dimensional instead of three."
Unlike Kipp, Shwarm is a native of the state, born in Greensburg in central Kansas. He also is a KU graduate and is the degree under the guidance of Iversen.
Some of the portraits in the exhibit were done by Diane Covert, an instructor at the Kansas City Art Institute and a free lance artist. They also innate in the Jackson County. M., oal.
COVERT WAS hired by the Jackson County executives office last year to prepare a slide show for a bond issue campaign to improve the overcrowded
"While I was there doing the slide show," Covert said, "I became interested in the jail. Like any other group, it's a culture. They have a definite lifestyle."
Covert said that most of the photographs were taken through prison bars and that without cooperation from the inmates, she could not have taken the shots.
"At first there was some hostility, but then they realized I was just a person like them and they got to know me," she said.
Covert, from Kankakee, Ill., calls herself a Midwesterner not only because she grew up in the Midwest, but also because her "work has grown all lot here."
JON BLUMB also did portraits of people in the Midwest for the Union exhibit. Blumb is a graduate student in the School of Design, studying under Iversen.
His subjects range from a young waitress leaning against a truck-stop counter to a farm family posed around their tractor.
Iversen's photographs concentrate on the horses of the Midwest; in rodeos, with their owners, end as statues and plastic figures, during on the rooftops of bars and restaurants.
Kipp himself shot scenes throughout Kansas, portraying the architecture of small Midwestern towns.
"WHY DO THE HEATHEN RAGE?"
Psalms 2:1 and Acts 4:25
"Ye that love the Lord hate will." Take thou away from me the noise of the sounds, for I will not hear the melody of the vows. But let judgment run down as waters, and water is as a mighty stream!" Psalm 7:10 and Amos 5:23 and 24
One may love the great hymn and music of the Church, but if one does not "hate the church" it appears God does not appoint it.
I have thought of my life as an arrow shot out of a bow: for a moment it is seen as it takes its flight across the landscape, then drops into obscurity. Let me be a man of ONE BOOK, that of my fellow men, that when I drop out of sight into obscurity I may be "Sae in The Ama of Jesus." This is not a quote, but a quote, based on a statement of John Wesley.
upon the unrepentant, God would require the blood lost souls at their hands. Read Ecclestion 3:17; and, chapters 18
In one respect it suggested he was mistaken, for the light he reflected on One Book he almost not felt monochromatic. One book he ashamed not for monochromatic landscapes; very limited landscape not at all, but across the landscape of most of the world. He, and the "people called Methodol." they had, were not so aware of the landscape. man of God. They were especially noted, and offensive to many, for rebuking sin where they saw it. the sin of any man, in their view. And as a man of God, "Oft they suffered for it, but the reason they gave for it was to show that God had no mercy for if they did not warn men of God's warts and come to sense
"The heart in your bosom is a 'muffled drum' beating out to the墓地 for the you." When they take you and me to the home of clay, and go to the "long house", and back to the "home of clay" and go to the "long house", and back to the "home of clay" and go to the "long house". One where "eye hath not seen, ear hath not heard, hand hath not seen, hand hath not heard, hand hath prepared for that love him," . . . the most thing I capsize of thinking of or imagining the great good, joy and happiness.
We mouth much about the "T love of God" but it would be hard to remember what Jesus did when he said, "what manner it is manifested, Jesus Christ that in order that the word might know that He loved God, He obeyed him." This was a simple fact that He had to know. He rose, and went to meet the mob, the cross, an most of His disciples.
The other "long home" is the "take of fire" prepared for the other and his angels, raging and unrepentant men and nations. The wicked will be burned into hell, and all the nations that will be turned to fire will once once
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