8
University Daily Kansan
Thursday, Sept. 5, 1985
Campus/Area
Prof to research blood pressure tests
By Liz Maggard Of the Kansan staff
Ruben D. Bunag, professor of pharmacology at the University of Kansas Medical Center, has received a $245,232 grant from the Heart, Lung and Blood Institute of the National Institute of Traditional methods of collecting blood pressure research data from laboratory rats.
Financing for the project started Aug. 1, Bunag said yesterday. The grant covers a four-year period.
Bunag said that much of the research on hypertension was done with rats as test animals and that it is possible to provide good pressure readings to be accurate.
The current "tail cuff" method of taking a rat's blood pressure resembles the procedure for humans,
he said. The cuff is wrapped around the rat's tail, and the reading is taken.
Bunag said the tail cuff method had been used for the past 40 years, and he said he thought he was the only one concerned with its accuracy.
"I'm a lone voice shooting in the wilderness," he said.
Bunag said he disagreed with scientists who accepted tail cuff readings as both accurate and easy to obtain.
He said that to a person who had a tendency toward hypertension, the mere act of having blood pressure taken could be stressful and could cause an elevated reading. The tail cuff method creates the same kind of stress in rats and affects the readings in the same way, he said.
Other problems with the tail cuff
Bunag said it was easy to get an accurate blood pressure reading using a tail cuff on an anesthesized rat, but such readings were not considered acceptable for use in studying chronic diseases such as hypertension.
method are caused by the rat's physiology, Bunag said. He said that a rat's tail was its main organ for controlling body temperature and that the blood vessels in the tail reacted to changes in temperature by dilating or constricting as a way of releasing or conserving heat.
He said he thought reliance on tail cuff readings created a problem with wide implications in hypertension research because of the extensive use of rats. He said he hoped to determine the extent and nature of the inaccuracies in tail cuff data as
well as develop an alternative method that would provide more accurate results.
Bunga said he would explore the use of a rat's hind leg as an alternative method because the blood vessels in the hind leg were not as reactive as those in the tail. He said they had about 20 years ago, but the equipment used in that method no longer was available.
Gunther Schlager, chairman of the division of biological sciences, said he used the hind leg method with hamsters because they had no tails, but he used the tail cuff method with mice. He agreed with Bunag that collecting data by this method could be stressful on the animal, but he said there were methods to reduce such stress.
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