University Daily Kansan / Wednesday, January 20. 1988
9
One in three inherits risk
Doctors link heart disease genetic trait
The Associated Press
NEW ORLEANS — An estimated one in three Americans inherits a newly recognized form of cholesterol that is linked with triple the usual risk of heart disease, according to research released yesterday.
"We have identified a new genetic trait that may predispose to heart disease risk," said Dr. Ronald M. Krauss of the University of California, where he described his work at a meeting of the American Heart Association.
Although Krauss has not pinpointed the gene that is responsible, he said its hallmark in the bloodstream is a substance called dense LDL, which can be measured with a blood test.
About one-third of the population has relatively large amounts of dense LDL, and they are three times more likely than usual to suffer heart attacks. Krauss said.
Not all of these people will have heart attacks, and dense LDL itself may not even be the culprit. Instead, it may be a genetic marker, or signal, that they are at higher than usual risk.
Krauss said that such people may be unusually susceptible to the dangers of bad living habits that are often associated with heart trouble. These include obesity, a high-fat diet, lack of exercise and poorly controlled blood pressure.
When the heart gets into trouble, it is usually because fatty deposits of cholesterol build up on the walls of arteries that feed the heart. A heart attack occurs when when one of these arteries is plugged. The heart muscle is starved of blood, and some of it dies.
Cholesterol doesn't float through the bloodstream by itself. Instead, it is bound up in particles of protein. Ordinarily, doctors think of two kinds
of particles known as HDL and LDL.
HDL, or high-density lipoprotein, is the so-called good cholesterol. It gathers up cholesterol and carries it away. Its counterpart, LDL or low-density lipoprotein, transports the fats deposited on the blood vessel walls.
Krausss based his estimate that one in three people has a copy of the gene on studies of the blood of 2,000 individuals.
Krauss, working with researchers from Harvard and Rockefeller universities, studied 109 heart attack victims. Their dense LDL levels were compared with those of a group of 121 healthy people.
Although their total LDL levels were the same, there was a significant difference in how much dense LDL they had. A statistical analysis of the two groups revealed a threefold increase in the risk of heart attack associated with dense LDL in both men and women.
Krauss and colleagues have discovered that there are actually two categories of LDL: a light variety and a dense type.
guess what? what?
January 22 is almost here and your walls are still ugly.
come check out the Picture Lending Library.
where ? Browsing Room Kansas Union
When? January 22
From 10 a.m.-4 p.m.
what am I going to
get out of? If you
may be asking? No!
You can get GREAT
FRAMED PICTURES
and... rent them
cheap For this
semester.
sponsored by the people a + SUA
Photos by Nathan Ham
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